Key result
An increase in serum cystatin C level was independently associated with the risk of subclinical atherosclerosis in patients with type 2 diabetes (OR 1.200; 95% CI 1.04-1.38; p=0.011).
Why the study?
Is serum cystatin C level associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus?
Observational (n=523)
Is serum cystatin C level associated with subclinical atherosclerosis in patients with type 2 diabetes mellitus?
Serum cystatin C level is independently associated with subclinical atherosclerosis in patients with type 2 diabetes, suggesting its potential as a surrogate marker for cardiovascular risk.
Cystatin C was associated with subclinical atherosclerosis in T2DM; hypothesis-generating and should not yet change practice.
BACKGROUND: The aim of this study was to investigate the association between the serum cystatin C level and cardiovascular disease risk in patients with type 2 diabetes mellitus. METHODS: We studied 523 patients with type 2 diabetes mellitus and calculated estimated 10-year risk of atherosclerotic cardiovascular disease (%). Subclinical atherosclerosis was defined as brachial-ankle pulse wave velocity ⩾1700 ms, indicating the presence of arterial stiffness. RESULTS: Cystatin C level was significantly higher in the subclinical atherosclerosis group (brachial-ankle pulse wave velocity ⩾ 1700 ms) than in the non-subclinical atherosclerosis group (brachial-ankle pulse wave velocity < 1700 ms) (7.54 ± 3.15 mg/L vs 10.04 ± 5.12 mg/L, p < 0.001). Subclinical atherosclerosis was mainly determined by age, duration of diabetes and cystatin C level, but not by serum creatinine, 10-year risk of atherosclerotic cardiovascular disease score and estimated glomerular filtration rate in the multiple linear regression analysis. In addition, an increase in cystatin C level was independently associated with the risk of subclinical atherosclerosis after adjusting for age, sex, duration of diabetes, smoking, hypertension, 10-year risk of atherosclerotic cardiovascular disease risk score, serum creatinine level, total cholesterol, high-density lipoprotein cholesterol and haemoglobin A1c (odds ratio = 1.200, 95% confidence interval: 1.04-1.38, p = 0.011). CONCLUSION: Serum cystatin C level was significantly associated with subclinical atherosclerosis. This result suggests that an increase in cystatin C level could be a valuable surrogate marker for the risk of cardiovascular disease in patients with type 2 diabetes mellitus.
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Chung et al. (2017) conducted an observational in type 2 diabetes mellitus (n=523). Serum cystatin C was evaluated on subclinical atherosclerosis (brachial-ankle pulse wave velocity ≥1700 ms) (OR 1.200, 95% CI 1.04-1.38, p=0.011). An increase in serum cystatin C level was independently associated with the risk of subclinical atherosclerosis in patients with type 2 diabetes (OR 1.200; 95% CI 1.04-1.38; p=0.011).
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