Key result
A serum cystatin C level above /L was associated with an increased risk of cardiovascular disease in patients with type 2 diabetes.
Why the study?
Is elevated serum cystatin C associated with an increased risk of cardiovascular disease in patients with type 2 diabetes?
Observational (n=72)
Is elevated serum cystatin C associated with an increased risk of cardiovascular disease in patients with type 2 diabetes?
Elevated serum cystatin C (>1.10 mg/L) may serve as a potential biomarker for cardiovascular disease in patients with type 2 diabetes.
Answers are grounded in this paper and cite their sources.
Elevated cystatin C should not yet guide CVD risk assessment in type 2 diabetes; hypothesis-generating and requires prospective validation.
Serum cystatin C concentration was recently reported as a marker of cardiovascular disease (CVD). In the present study, we evaluated the association between the increase of serum cystatin C levels and the risk of CVD in type 2 diabetes. 42 patients with type 2 diabetes were included in the present study; 27 of them have CVD. The control group consisted of 30 healthy adults. Cystatin C, creatinine, microalbuminuria and CRP were measured on Cobas 6000(TM). Cystatine C level was significantly higher in patients with CVD. A significant difference in serum cystatin C was found in patients with and without CVD among albuminuria. No difference in serum cystatin C levels was found according to number of affected vessels. A cystatin C level above 1.10 mg/L was associated with increase of risk of CVD with significant difference (OR = 42.52; IC 95% 1.455 to 1242.827 and p = 0.029). Our results suggested that the increase of serum cystatin C concentrations is a potential marker for CVD in diabetes.
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Triki et al. (2013) conducted an observational in Type 2 diabetes and cardiovascular disease (n=72). Serum cystatin C level > 1.10 mg/L vs. Healthy controls / lower cystatin C levels was evaluated on Risk of cardiovascular disease (OR 42.52, 95% CI 1.455 to 1242.827, p=0.029). A serum cystatin C level above /L was associated with an increased risk of cardiovascular disease in patients with type 2 diabetes.
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