Key result
Elevated cystatin C tracks with higher mortality and CV risk in diabetes, outperforming traditional markers.
Why the study?
Cystatin C has been highlighted as a promising early marker of cardiovascular risk in diabetic patients due to its relationship with renal function and inflammation, but its association and effectiveness needed systematic evaluation.
Is Cystatin C associated with cardiovascular risk in patients with diabetes?
Systematic Review
Is Cystatin C associated with cardiovascular risk in patients with diabetes?
Cystatin C is a promising early marker for cardiovascular risk and mortality in patients with diabetes, potentially outperforming traditional markers.
Supports cystatin C for refined CV risk stratification in diabetes; extends prior evidence via systematic confirmation of superior accuracy.
Introduction: cystatin C, a protein with stable plasma concentration and exclusive renal elimination, has been highlighted as a promising early marker of cardiovascular risk in diabetic patients due to its relationship with renal function and inflammation.Objective: to identify in the existing literature the association between Cystatin C and cardiovascular risk in patients with diabetes, evaluating its potential as a marker by means of a systematic review.Methods: we performed exhaustive searches of scientific databases and selected ten studies that met the inclusion criteria. These studies focused on the evaluation of Cystatin C expression profiles and their effectiveness as a marker in the diagnosis and prognosis of cardiovascular disease. The PRISMA method was used.Results: the studies reveal that cystatin C is closely associated with type 2 diabetes, predicts cardiovascular disease, and provides an accurate assessment of renal function in diabetic patients, highlighting its usefulness as an early marker of complications. Furthermore, elevated cystatin C levels correlate with increased mortality and cardiovascular risk, surpassing in accuracy other traditional markers, positioning it as a key indicator in the comprehensive assessment of risk and prognosis in diabetic patients.Conclusions: cystatin C shows promising links with diabetes and cardiovascular risk in diabetic patients, suggesting its usefulness as an early marker. Although it offers the potential for detecting renal and cardiac complications, further research is required before its widespread clinical implementation
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Tisalema-Panimboza et al. (2023) conducted a systematic review in Diabetes and cardiovascular risk. Elevated Cystatin C vs. Normal Cystatin C levels or traditional markers was evaluated on Cardiovascular risk and mortality prediction. Elevated cystatin C levels correlate with increased mortality and cardiovascular risk in diabetic patients, surpassing traditional markers in accuracy.
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