Key result
Whole-genome sequencing of 72 HAdV-55 isolates from 1969 to 2018 revealed a high degree of genomic homogeneity worldwide (<0.38% nucleotide divergence), with distinct strains circulating regionally for several years.
Why the study?
HAdV-55 causes acute respiratory disease and is endemic to China and South Korea, but data from other regions and time periods are needed for comprehensive global assessment.
Observational (n=72)
Yes
HAdV-55 shows worldwide distribution with high genomic homogeneity and persistent regional transmission, highlighting the need for enhanced molecular surveillance.
Supports enhanced HAdV-55 molecular surveillance; leaves open questions on clinical impact and transmission dynamics.
Human adenovirus type 55 (HAdV-55) causes acute respiratory disease of variable severity and has become an emergent threat in both civilian and military populations. HAdV-55 infection is endemic to China and South Korea, but data from other regions and time periods are needed for comprehensive assessment of HAdV-55 prevalence from a global perspective. In this study, we subjected HAdV-55 isolates from various countries collected during 1969-2018 to whole-genome sequencing, genomic and proteomic comparison, and phylogenetic analyses. The results show worldwide distribution of HAdV-55; recent strains share a high degree of genomic homogeneity. Distinct strains circulated regionally for several years, suggesting persistent local transmission. Several cases of sporadic introduction of certain strains to other countries were documented. Among the identified amino acid mutations distinguishing HAdV-55 strains, some have potential impact on essential viral functions and may affect infectivity and transmission.
No takes yet. Share an insight, caveat, or question.
Hang et al. (2020) conducted an observational in Human Adenovirus Type 55 (HAdV-55) infection (n=72). HAdV-55 isolates was evaluated on Genomic nucleotide divergence and phylogenetic clustering. Whole-genome sequencing of 72 HAdV-55 isolates from 1969 to 2018 revealed a high degree of genomic homogeneity worldwide (<0.38% nucleotide divergence), with distinct strains circulating regionally for several years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: