Why the study?
Does the combination of T-786-->C polymorphism and smoking increase the risk of coronary spasm in patients without significant coronary stenosis?
Population
447 patients admitted for evaluation of chest pain, with no significant coronary stenosis, undergoing…
Comparison
Presence of T-786-->C polymorphism combined with… vs Non-smokers with T/T genotype, non-smokers with…
Design
Cross-sectional
Authors
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Supports eNOS-smoking synergy for spasm risk; hypothesis-generating and requires prospective validation before any clinical use.
Does the combination of T-786-->C polymorphism and smoking increase the risk of coronary spasm in patients without significant coronary stenosis?
The combination of the T-786-->C polymorphism in the eNOS gene and smoking synergistically increases the risk of acetylcholine-induced coronary spasm.
Nakayama et al. (2003) studied this question.
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