NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: The Atherosclerosis Risk in Communities study
Why the study?
Does cigarette smoking modify the association between NOS3 polymorphisms and the risk of coronary heart disease or stroke?
Population
2,450 individuals from the Atherosclerosis Risk in Communities study, including 1,085 incident coronary…
Comparison
Presence of NOS3 polymorphisms and cigarette… vs Absence of variant alleles and non-smoking status
Design
Cohort
Authors
Discussion
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Member takes
Overview
May support ancestry-specific CVD risk stratification in smokers; leaves open clinical utility of NOS3 testing pending validation.
Structured PICO
Does cigarette smoking modify the association between NOS3 polymorphisms and the risk of coronary heart disease or stroke?
P
Population
2,450 individuals from the Atherosclerosis Risk in Communities study, including 1,085 incident coronary heart disease cases, 300 incident ischemic stroke cases, and 1,065 reference individuals
I
Intervention
Presence of NOS3 polymorphisms (T-786C and E298D) and cigarette smoking
C
Comparator
Absence of variant alleles and non-smoking status
O
Outcome
Incident coronary heart disease or ischemic strokehard clinical
Cigarette smoking significantly modifies the association between NOS3 polymorphisms and the risk of incident coronary heart disease and ischemic stroke, highlighting a gene-environment interaction in cardiovascular risk.
Cite This Study
Lee et al. (2006) studied this question.