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November 1, 2001Hypertension

Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease

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Why the study?

Do NOS 3 gene polymorphisms or plasma NOx levels predict the risk of ischemic heart disease in middle-aged men?

Population

3052 middle-aged men initially free of ischemic heart disease, recruited from 9 UK primary care practices.

Design

Cohort

Follow-up

8.1 years

Authors

NJNoor JeerooburkhanGreat Ormond Street HospitalLJLisa C. JonesBrigham Young UniversitySBSarah R. BujacRedx Pharma (United Kingdom)

Discussion

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Overview

Lower NOx in smokers was independent of NOS3 genotype and IHD risk; leaves open whether NOx or these variants predict events in middle-aged men.

Structured PICO

Do NOS 3 gene polymorphisms or plasma NOx levels predict the risk of ischemic heart disease in middle-aged men?

P
Population
3052 middle-aged men initially free of ischemic heart disease (IHD), recruited from 9 UK primary care practices.
I
Intervention
NOS 3 gene polymorphisms (-786 T/C, -922 A/G, 894 G/T, eNOS4a/4b), smoking status, serum cholesterol, and blood pressure
O
Outcome
Plasma levels of nitrogen oxides (NOx) and risk of ischemic heart disease (IHD)hard clinical

While smoking is associated with reduced NO bioactivity, NOS 3 genotype does not appear to influence plasma NOx levels or IHD risk in middle-aged British men.

Cite This Study

Jeerooburkhan et al. (2001) studied this question.

synapsesocial.com/papers/6a79e2fe2eb3c7e469f3c3d6https://doi.org/10.1161/hy1101.092967
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial Nitric Oxide Synthase Gene Variants and Coronary Heart Disease2012 · 3 citations
  2. 2NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: The Atherosclerosis Risk in Communities study2006 · 29 citations
  3. 3Lack of evidence for constribution of intron4a/b polymorphism of endothelial nitric oxide synthase (NOS3) gene to plasma nitric oxide levels2008 · 13 citations
  4. 4Association of plasma nitric oxide concentration and endothelial nitric oxide synthase T-786C gene polymorphism in coronary artery disease2012 · 28 citations
  5. 5Association between Endothelial Nitric Oxide Synthase Polymorphisms and Risk of Metabolic Syndrome2013 · 11 citations