Key result
The NOS3 T-786C TC+CC genotype was significantly associated with a decreased risk of metabolic syndrome compared to the TT genotype (OR 0.63; 95% CI 0.43-0.91).
Why the study?
Are NOS3 gene polymorphisms associated with the risk of metabolic syndrome?
Population
1,122 individuals recruited at a central Taiwanese hospital.
Comparison
NOS3 gene polymorphisms vs Common/wild-type genotypes
Design
Case-control
Authors
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Should not yet alter metabolic syndrome risk assessment; leaves open need for prospective validation of NOS3 variants.
Case-Control (n=1,122)
No
Are NOS3 gene polymorphisms associated with the risk of metabolic syndrome?
Effect estimate: OR 0.63 (95% CI 0.43-0.91)
The NOS3 T-786C and intron 4b/a polymorphisms are associated with a decreased risk of metabolic syndrome, particularly among smokers and non-drinkers.
Liu et al. (2013) conducted a case-control in Metabolic syndrome (n=1,122). NOS3 T-786C TC+CC genotype vs. NOS3 T-786C TT genotype was evaluated on Risk of metabolic syndrome (OR 0.63, 95% CI 0.43-0.91). The NOS3 T-786C TC+CC genotype was significantly associated with a decreased risk of metabolic syndrome compared to the TT genotype (OR 0.63; 95% CI 0.43-0.91).
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