Key result
The NOS3 774T/894T haplotype was significantly associated with an increased risk of metabolic syndrome in the Russian population (OR 2.18).
Why the study?
Are NOS3 genetic variants and their haplotypes associated with the risk of metabolic syndrome in schizophrenia patients and healthy subjects?
Case-Control (n=515)
Yes
Are NOS3 genetic variants and their haplotypes associated with the risk of metabolic syndrome in schizophrenia patients and healthy subjects?
NOS3 genetic variants, particularly the T-786C promoter polymorphism and haplotypes of G894T and C774T, are associated with metabolic syndrome susceptibility in the Russian population.
Answers are grounded in this paper and cite their sources.
Should not yet inform genetic risk assessment; leaves open NOS3 haplotype relevance beyond Russian cohorts.
BACKGROUND/OBJECTIVES: The frequency of metabolic syndrome (MetS) is significantly higher in schizophrenia (SCH) patients, when compared to the general populatiotin. The goal of this study was to evaluate whether genetic variants T-786C (rs2070744), G894T (rs1799983) and C774T (rs1549758) in the endothelial nitric oxide (NOS3) gene and/or their haplotypes could be associated with the risk of MetS in SCH patients or healthy subjects from Russian population. SUBJECTS/METHODS: We performed two case-control comparisons. NOS3 polymorphisms were genotyped in 70 SCH patients with MetS, 190 normal weight SCH patients, 155 MetS patients, and 100 healthy controls. MetS was defined as per the criteria proposed by the International Diabetes Federation (IDF). Anthropometric, clinical, biochemical parameters, and serum nitrite concentrations were measured in all samples. Haplotype frequency estimations and linkage disequilibrium measures were made using Haploview 4.2. RESULTS: The higher C allele (P = 0.009) and lower TT genotype (P = 0.008) frequencies of T-786C polymorphism were found in SCH patients with MetS compared to those in normal weight SCH patients. SCH patients with MetS who were carriers of the T-786C TT genotype had lower serum total cholesterol levels in comparison to the CC genotype (P = 0.016). Furthermore, the 774T/894T haplotype was more frequent in non-SCH individuals with MetS compared to healthy controls (P = 0.0004, odds ratio = 2.18, 95% confidence interval 1.4-3.37). Conversely, the most common haplotype 774C/894G was less frequent in MetS patients than in healthy controls (P = 0.013, odds ratio = 0.61, 95% confidence interval 0.41-0.9). CONCLUSIONS: These results indicate that the NOS3 T-786C promoter polymorphism was closely associated with MetS risk in SCH patients. In addition, the haplotypes composed of G894T and C774T polymorphisms are associated with the MetS susceptibility in Russian population.
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Fattakhov et al. (2018) conducted a case-control in Metabolic syndrome in schizophrenia patients and general population (n=515). NOS3 774T/894T haplotype vs. Healthy controls was evaluated on Metabolic syndrome susceptibility associated with the 774T/894T haplotype in non-schizophrenia individuals (OR 2.18, 95% CI 1.4-3.37, p=0.0004). The NOS3 774T/894T haplotype was significantly associated with an increased risk of metabolic syndrome in the Russian population (OR 2.18).
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