Key result
NOS3 rs1799983 and rs2070744 polymorphisms were not significantly associated with unstable angina in a comparison of 246 patients and 189 healthy controls.
Why the study?
Previous studies suggested NOS3 polymorphisms may be associated with acute coronary syndromes, but their specific association with unstable angina needed evaluation.
Are NOS3 rs1799983 and rs2070744 polymorphisms associated with unstable angina?
Population
246 patients with angiographically confirmed unstable angina and 189 healthy controls
Comparison
Patients with unstable angina vs healthy controls across NOS3 rs1799983 and rs2070744 genotypes
Design
Case-control study
Authors
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No association in this cohort does not support genotyping for unstable angina risk; leaves open sex-specific obesity links in larger studies.
Case-Control (n=435)
Are NOS3 rs1799983 and rs2070744 polymorphisms associated with unstable angina?
NOS3 rs1799983 and rs2070744 polymorphisms do not appear to be associated with unstable angina, though they may have sex-specific associations with obesity parameters.
Pawlik et al. (2020) conducted a case-control in Unstable angina (n=435). NOS3 rs1799983 and rs2070744 polymorphisms vs. Healthy controls was evaluated on Association with unstable angina. NOS3 rs1799983 and rs2070744 polymorphisms were not significantly associated with unstable angina in a comparison of 246 patients and 189 healthy controls.
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