Key result
Endothelial nitric oxide synthase 894G>T TT genotype is linked to metabolic syndrome in males.
Why the study?
The role of 894G>T endothelial nitric oxide synthase gene polymorphism in metabolic syndrome and its sex-related differences was unclear.
Does the 894G>T NOS3 polymorphism associate with metabolic syndrome and its components?
Case-Control (n=616)
Does the 894G>T NOS3 polymorphism associate with metabolic syndrome and its components?
The 894G>T NOS3 polymorphism is associated with metabolic syndrome in men and hypertension in women, suggesting a sex-specific genetic interaction with metabolic risk.
Supports sex-specific genetic predisposition to metabolic risk; hypothesis-generating and should not change practice pending replication.
Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.
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Piccoli et al. (2008) conducted a case-control in Metabolic syndrome (n=616). 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) vs. Control subjects was evaluated on TT genotype frequency (p=0.02). The 894G>T endothelial nitric oxide synthase TT genotype was significantly more frequent in males with metabolic syndrome than in control subjects (p=0.02).
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