SARS-CoV-2 Wuhan Strain Found by NGS in Feces of a Vaccinated Female Despite Repeat Negative Nasopharyngeal Swabs by PCR: A Case Report

The use of real-time reverse transcription-PCR (RT-PCR) testing to determine the presence or absence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be inadequate and inaccurate for individuals who have been vaccinated against the virus.This case demonstrates that individuals vaccinated against SARS-CoV-2 may later produce viral particles and viral variants that exist systemically and may be undetected solely by RT-PCR testing.Regarding fecal transplantation, further testing, including NGS, is required for individuals who serve as fecal donors to avoid cross-contamination and viral spread.