Reactivity of Mesenteric Arteries From Fructose Hypertensive Rats to Endothelin-1
Population
Male Sprague Dawley rats
Comparison
Chronic oral bosentan treatment initiated 1 week… vs Control diet, control diet with bosentan, and…
Design
Preclinical
Follow-up
16 weeks
Authors
Discussion
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Implication
Hypothesis-generating in rat fructose model; leaves open clinical translation of ET blockade for hypertension.
Structured PICO
P
Population
Male Sprague Dawley rats
I
Intervention
Chronic oral bosentan treatment (100 mg/kg/day) initiated 1 week prior to initiating the fructose diet and continued to week 16
C
Comparator
Control diet, control diet with bosentan, and fructose diet without bosentan
O
Outcome
Reactivity of mesenteric arteries to ET-1 and endothelium-dependent vasodilationsurrogate
Chronic ET receptor blockade with bosentan prevents hypertension and restores mesenteric artery reactivity to ET-1 in a rat model of fructose-induced hypertension.
Cite This Study
Subodh Verma (1997) studied this question.