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The reaction between 2-aminoimidazoles and aldehydes affords mono- and disubstituted hydroxyalkylaminoimidazoles and tetrahydropurine derivatives. The formation of the tetrahydropurine is believed to proceed via an intermolecular hetero [2+4] cycloaddition between 2-aminoimidazole and its corresponding Schiff base.
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Xu et al. (1993) studied this question.
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