What question did this study set out to answer?

Determine the prevalence of clarithromycin- and metronidazole-associated resistance mutations in Helicobacter pylori among endoscopy patients from a rural American Indian community.

June 30, 2023Open Access

Antibiotic Resistance Rates for Helicobacter pylori in Rural Arizona: A Molecular-Based Study

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Authors

FMFernando P. MonroyNorthern Arizona University HBHeidi E. BrownUniversity of Arizona CAClaudia M. Acevedo-SolisIndian Health Service

Discussion

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Implication

Cross-sectional study uncovers high rates of clarithromycin and metronidazole resistance mutations in rural Indigenous patients, highlighting the need for resistance-guided therapies.

Key Points

Determine the prevalence of clarithromycin- and metronidazole-associated resistance mutations in Helicobacter pylori among endoscopy patients from a rural American Indian community.
Recruited 396 endoscopy patients in Northern Arizona between 2018 and 2021, identifying 67 H. pylori-positive gastric biopsy specimens.
Sequenced the 23S ribosomal RNA and rdxA genetic loci across 64 samples from 49 treatment-naive individuals.
Extracted clinical history and endoscopic findings from medical records and evaluated sex-specific variation in mutation frequency.
Clarithromycin resistance-associated mutations were detected in 38.8% of individuals, with the T2182C variant accounting for 90% of these mutations.
Metronidazole resistance-associated mutations were present in 93.9% of individuals, predominantly driven by D95N and L62V substitutions.
No statistically significant sex-based differences were identified for resistance mutations to either clarithromycin or metronidazole.

Cite This Study

Monroy et al. (2023) studied this question.

synapsesocial.com/papers/6a9829ed9f0d7a8a1afacf8e https://doi.org/10.20944/preprints202306.2193.v1

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Implication

Cross-sectional study uncovers high rates of clarithromycin and metronidazole resistance mutations in rural Indigenous patients, highlighting the need for resistance-guided therapies.

Antibiotic Resistance Rates for Helicobacter pylori in Rural Arizona: A Molecular-Based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Antibiotic Resistance Rates for Helicobacter pylori in Rural Arizona: A Molecular-Based Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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