December 1, 2004DiabetesOpen Access

ATP-Sensitive K+ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits

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Structured PICO

Population

Mice lacking functional Kir6.2-containing K(ATP) channels (Kir6.2-KO) and wild-type controls

Intervention

28-day endurance swimming protocol

Comparator

Wild-type controls undergoing the same swimming protocol

Outcome

Exercise capacity, body fat composition, glycemic handling, survival, and cardiac performance

Kir6.2-containing K(ATP) channels are essential for mediating the physiological and metabolic benefits of exercise training and protecting the heart from exercise-induced injury.

Discussion

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Implication

Kir6.2 K(ATP) channels may mediate exercise cardioprotection; hypothesis-generating in mice and requires human validation before clinical relevance.

Cite This Study

Kane et al. (2004) studied this question.

synapsesocial.com/papers/6a982d31329299b5dce34a79 https://doi.org/10.2337/diabetes.53.suppl_3.s169

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Implication

Kir6.2 K(ATP) channels may mediate exercise cardioprotection; hypothesis-generating in mice and requires human validation before clinical relevance.

ATP-Sensitive K+ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits

Structured PICO

Discussion

Implication

Cite This Study

ATP-Sensitive K+ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider