Key result
The GALNT2 rs4846914_G allele was significantly associated with increased ANGPTL3 (p≤0.05), higher BMI and weight (p<0.003), increased ApoC1 (p≤0.006), and reduced HDL levels (p≤0.05).
Why the study?
GALNT2 rs4846914 is linked to lipid levels in Europeans, but its association with ANGPTL proteins, apolipoproteins, lipids, and obesity traits in Arab individuals remained to be evaluated.
Is the GALNT2 rs4846914 variant associated with obesity, atherogenic lipid traits, and ANGPTL3 plasma levels in Arab individuals?
Cross-Sectional (n=278)
Is the GALNT2 rs4846914 variant associated with obesity, atherogenic lipid traits, and ANGPTL3 plasma levels in Arab individuals?
p-value: p=≤ 0.05
The GALNT2 rs4846914 variant is associated with adverse lipid profiles and obesity traits in an Arab cohort, suggesting a potential genetic link between lipid metabolism and obesity.
Supports GALNT2-lipid-obesity links in Arabs; extends prior findings but leaves open causality and clinical utility.
N-Acetylgalactosaminyltransferase 2 (GALNT2) is associated with serum lipid levels, insulin resistance, and adipogenesis. Additionally, angiopoietin-like (ANGPTL) proteins have emerged as regulators of lipoprotein lipase and lipid metabolism. In this study, we evaluated the association between GALNT2 rs4846914 variant, known for its association with lipid levels in European cohorts, with plasma levels of ANGPTL proteins, apolipoproteins, lipids, and obesity traits in individuals of Arab ethnicity. GALNT2 rs4846914 was genotyped in a cohort of 278 Arab individuals from Kuwait. Plasma levels of ANGPTL3 and ANGPTL8 were measured by ELISA and apolipoproteins by Luminex multiplexing assay. Allele-based association tests were performed with Bonferroni-corrected p-value thresholds. The GALNT2 rs4846914_G allele was associated with increased ANGPTL3 (p-values ≤ 0.05) but not with ANGPTL8 plasma levels. The allele was associated significantly with higher BMI and weight (p-values < 0.003), increased ApoC1 levels (p-values ≤ 0.006), and reduced HDL levels (p-values ≤ 0.05). Individuals carrying the GG genotype showed significantly decreased HDL and increased BMI, WC, ApoC1, and TG. Interactions exist between (AG+GG) genotypes and measures of percentage body fat, ApoA1A, ApoC1, and ApoB48-mediated HDL levels. GALNT2 is confirmed further as a potential link connecting lipid metabolism and obesity and has the potential to be a drug target for treating obesity and dyslipidemia.
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Qaddoumi et al. (2022) reported a cross-sectional. GALNT2 rs4846914_G allele was evaluated on Plasma levels of ANGPTL3, ANGPTL8, apolipoproteins, lipids, and obesity traits (p=≤ 0.05). The GALNT2 rs4846914_G allele was significantly associated with increased ANGPTL3 (p≤0.05), higher BMI and weight (p<0.003), increased ApoC1 (p≤0.006), and reduced HDL levels (p≤0.05).
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