January 30, 2025Journal of Ginseng ResearchOpen Access

Effects of red ginseng extract and red ginseng dietary fiber on the maintenance of intestinal immune and functional homeostasis in diet-induced obese mice

Q: What is the clinical evidence from this study?

Study design: Other. Population: Diet-induced obesity and intestinal inflammation. Intervention: Red ginseng extract powder (RGEP) and Red ginseng dietary fiber (RGDF) vs. High-fat diet (HFD) control and Low-fat diet (LFD) normal control. Primary outcome: Intestinal immune and functional homeostasis (including bowel transit, mucosal barrier integrity, and inflammatory cytokines) (p=<0.05).

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Key result

Administration of red ginseng extract powder or red ginseng dietary fiber significantly recovered impaired bowel function, mucosal barrier integrity, and intestinal immune homeostasis in diet-induced obese mice (p<0.05).

Why the study?

Obesity is an important risk factor for intestinal inflammatory disease, prompting evaluation of red ginseng extract powder and dietary fiber on intestinal immune and functional homeostasis.

Population

Diet-induced obese C57BL/6 male mice

Comparison

RGEP vs FOS vs RGDF

Design

Preclinical animal study

Follow-up

4-8 weeks

Authors

SSSeung‐Hwan SeoSeoul National University DHDo-Won HamSeoul National University JLJieun LeeSeoul National University

Discussion

Member takes

Implication

Preclinical gut recovery in obese mice; leaves open human translation and trials before any clinical use.

Structured PICO

Population

Male C57BL/6 mice with diet-induced obesity, treated with red ginseng extract or dietary fiber for 4 to 8 weeks to evaluate intestinal immune and functional homeostasis.

Intervention

Red ginseng extract powder (205, 410, or 820 mg/kg) or Red ginseng dietary fiber (410, 820, or 1640 mg/kg) administered orally once daily for 4-8 weeks

Comparator

High-fat diet (positive control) and low-fat diet (normal control)

Outcome

Maintenance of intestinal immune and functional homeostasis (evaluated via stool trait, gastrointestinal motility, inflammatory biomarkers and cytokines, mucosal protective genes, bacterial toxicity, and histopathological features)surrogate

Main Result

p-value: p=<0.05

Red ginseng extract and dietary fiber may help restore intestinal immune and functional homeostasis impaired by diet-induced obesity in a mouse model.

Limitations

The compositions of components of RGEP and RGDF are similar, limiting the ability to compare their distinct effects.
Lack of microbiome data to accurately verify the prebiotic efficacy of RGEP and RGDF in relation to intestinal health.

Cite This Study

Seo et al. (2025) studied Diet-induced obesity and intestinal inflammation. Red ginseng extract powder (RGEP) and Red ginseng dietary fiber (RGDF) vs. High-fat diet (HFD) control and Low-fat diet (LFD) normal control was evaluated on Intestinal immune and functional homeostasis (including bowel transit, mucosal barrier integrity, and inflammatory cytokines) (p=<0.05). Administration of red ginseng extract powder or red ginseng dietary fiber significantly recovered impaired bowel function, mucosal barrier integrity, and intestinal immune homeostasis in diet-induced obese mice (p<0.05).

synapsesocial.com/papers/6a982d661a776067eb23c20e https://doi.org/10.1016/j.jgr.2025.01.006

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Effects of red ginseng extract and red ginseng dietary fiber on the maintenance of intestinal immune and functional homeostasis in diet-induced obese mice

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Effects of red ginseng extract and red ginseng dietary fiber on the maintenance of intestinal immune and functional homeostasis in diet-induced obese mice

Discussion

Member takes

Implication

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider