Key result
In healthy middle-aged Japanese men, the annual increase in arterial stiffness, but not pressure wave reflection, showed a significant longitudinal association with the annual decline in cardiac systolic performance (estimate 0.69 x 10^-4, p<0.01).
Why the study?
To examine the individual longitudinal associations of increases in arterial stiffness and pressure wave reflection with the decline in cardiac systolic performance in healthy middle-aged Japanese men.
Observational (n=4,016)
No
In healthy middle-aged men, longitudinal increases in arterial stiffness (baPWV), but not pressure wave reflection (rAI), are significantly associated with a decline in cardiac systolic performance.
Supports arterial stiffness as potential driver of systolic decline; hypothesis-generating and should not yet change practice.
AIMS: This prospective observational study aimed to examine the individual longitudinal associations of the increases in the arterial stiffness and pressure wave reflection with the decline in the cardiac systolic performance during the study period in healthy middle-aged Japanese men. METHODS: In 4016 middle-aged Japanese healthy men (43±9 years), the brachial-ankle pulse wave velocity (baPWV), radial augmentation index (rAI), and pre-ejection period/ejection time (pre-ejection period (PEP)/ET) were measured annually during a 9-year study period. CONCLUSION: In apparently healthy middle-aged Japanese men, the annual increase of the arterial stiffness, rather than the annual increase of the pressure wave reflection, appears to be more closely associated with the annual decline of the cardiac systolic performance as assessed by the systolic time interval.
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Kumai et al. (2021) conducted an observational in Healthy (n=4,016). Arterial stiffness (brachial-ankle pulse wave velocity) vs. Unexposed/lower arterial stiffness was evaluated on Longitudinal association with pre-ejection period/ejection time (PEP/ET) ratio (estimate 0.69 x 10^-4, p=<0.01). In healthy middle-aged Japanese men, the annual increase in arterial stiffness, but not pressure wave reflection, showed a significant longitudinal association with the annual decline in cardiac systolic performance (estimate 0.69 x 10^-4, p<0.01).
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