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January 1, 2013Internal MedicineOpen Access

Changes in Ankle Brachial Pulse Wave Velocity during a Five-Year Follow-up Period in Older Japanese Adults: Sub-analysis Results of the Health Research Volunteer Study in Japan

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Why the study?

Do antihypertensive medications prevent the progression of arterial stiffness (measured by baPWV) in older adults?

Population

257 socially active older Japanese adults over the age of 70 years.

Comparison

Antihypertensive medications. vs Normotensive individuals and hypertensive…

Design

Cohort

Follow-up

5 years

Authors

NDNobutaka DobaHiratsuka City HospitalYTYasuharu TokudaOkinawa Red Cross HospitalHTHirofumi TomiyamaPreventive Cardiology

Discussion

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Member takes

Overview

Antihypertensive use was associated with stable baPWV; leaves open whether therapy slows arterial stiffness progression independent of BP lowering.

Structured PICO

Do antihypertensive medications prevent the progression of arterial stiffness (measured by baPWV) in older adults?

P
Population
257 socially active older Japanese adults (115 men, baseline mean age 78±4 years; 142 women, baseline mean age 77±4 years) over the age of 70 years.
I
Intervention
Antihypertensive medications (either initiated during the follow-up period or received throughout the follow-up period).
C
Comparator
Normotensive individuals and hypertensive individuals without medication use.
O
Outcome
Changes in brachial-ankle pulse wave velocity (baPWV) and blood pressure over a five-year follow-up period.surrogate

Antihypertensive medications may protect against the age-related progression of arterial stiffness in older adults.

Cite This Study

Doba et al. (2013) studied this question.

synapsesocial.com/papers/6a7590ea3e2789f4c25ffd9ahttps://doi.org/10.2169/internalmedicine.52.8671
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Age-Specific Determinants of Brachial-Ankle Pulse Wave Velocity among Male Japanese Workers2021 · 5 citations
  2. 2ARTERIAL STIFFNESS ASSESSED BY BRACHIAL–ANKLE PULSE WAVE VELOCITY PREDICTS FUNCTIONAL DEPENDENCY IN COMMUNITY-DWELLING OLDER JAPANESE ADULTS: THE WAKAYAMA STUDY2026
  3. 3The Temporal Pattern of Arterial Stiffness during Aging: A Large-Scale Cross-Sectional Study2021 · 10 citations
  4. 4Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese2015 · 48 citations
  5. 5Brachial-ankle pulse wave velocity is an independent predictor of incident hypertension in Japanese normotensive male subjects2010 · 25 citations