Key result
The Framingham Risk Score was significantly correlated with brachial-ankle pulse wave velocity (r = 0.53, p < 0.01), indicating its applicability as an index of arterial stiffness.
Cohort (n=528)
Effect estimate: r = 0.53
p-value: p=<0.01
The Framingham Risk Score correlates significantly with brachial-ankle pulse wave velocity, indicating its applicability as an index of arterial stiffness in a healthy Japanese population.
Supports FRS for stiffness assessment in Japanese adults; leaves open validation and outcome impact in broader cohorts.
Arterial stiffness is one of the biggest predictors of coronary heart disease (CHD). We evaluated whether brachial-ankle pulse wave velocity (baPWV) and augmentation index (AI) are correlated with risk factors of CHD. All of the 528 participants (270 males and 258 females) in this study were healthy workers aged from 36 to 69 (mean age: 47.9 ± 8.1 years). The Framingham Risk Score (FRS) showed a good correlation with baPWV (r = 0.53, p < 0.01), indicating that FRS is also applicable as an index of arterial stiffness in Japanese people. Blood pressures were well controlled in patients with medical treatment for hypertension; however, vessels remained relatively still stiff, whereas the AI was considerably low. Multivariate linear regression analysis showed that factors of such as FRS, body mass index, alcohol consumption and AI P75 were significantly correlated with baPWV.
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Mitani et al. (2012) conducted a cohort in Healthy (n=528). Framingham Risk Score (FRS) and other CHD risk factors was evaluated on Correlation between Framingham Risk Score and brachial-ankle pulse wave velocity (baPWV) (r = 0.53, p=<0.01). The Framingham Risk Score was significantly correlated with brachial-ankle pulse wave velocity (r = 0.53, p < 0.01), indicating its applicability as an index of arterial stiffness.
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