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September 22, 2016Bioscience ReportsOpen Access

Prevalence of arterial stiffness and the risk of myocardial diastolic dysfunction in women

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Key result

Pathological aortic pulse wave velocity (≥9.7 m/s) was significantly associated with left ventricular diastolic dysfunction in women (OR 1.27; 95% CI 1.02-1.57).

Why the study?

Is arterial stiffness (measured by AIx and PWV) associated with left ventricular diastolic dysfunction in women?

Population

965 women aged 25-75 years from 12 districts of Berlin. A randomly selected subgroup was examined by…

Design

Cross-sectional

Authors

USUte SeelandGeneral CardiologyABAnna BrechtUniversity of LeedsANAhmad T. NaumanHumboldt-Universität zu Berlin

Discussion

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Implication

Association may aid risk stratification in women; leaves open causality and need for longitudinal validation before practice change.

Study Design

Type

Cross-Sectional (n=965)

Multicenter

No

Structured PICO

Is arterial stiffness (measured by AIx and PWV) associated with left ventricular diastolic dysfunction in women?

P
Population
965 women aged 25-75 years from Berlin evaluated for arterial stiffness and left ventricular diastolic dysfunction.
E
Exposure
Measurement of brachial augmentation index (AIx) and aortic pulse wave velocity (PWV) by an oscillometric method
O
Outcome
Prevalence of vascular dysfunction and arterial stiffness, and their association with left ventricular diastolic dysfunction (LVDD)surrogate

Main Result

Odds Ratio: 1.27 (95% CI 1.02–1.57)

Arterial stiffness, measured by aortic pulse wave velocity, is significantly associated with left ventricular diastolic dysfunction in women, suggesting its utility in cardiovascular risk assessment.

Cite This Study

Seeland et al. (2016) conducted a cross-sectional in Left ventricular diastolic dysfunction (n=965). Pathological aortic pulse wave velocity (≥9.7 m/s) vs. Normal pulse wave velocity was evaluated on Left ventricular diastolic dysfunction (LVDD) (OR 1.27, 95% CI 1.02-1.57). Pathological aortic pulse wave velocity (≥9.7 m/s) was significantly associated with left ventricular diastolic dysfunction in women (OR 1.27; 95% CI 1.02-1.57).

synapsesocial.com/papers/6a982ecb3de45e4adad7e105https://doi.org/10.1042/bsr20160276

Topics

CardiomyopathyWomen and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical applications of arterial stiffness, Task Force III: recommendations for user procedures2002 · 628 citations
  2. 2Echocardiographic Doppler evaluation of left ventricular diastolic function. Physics and physiology.1991 · 417 citations
  3. 3Arterial stiffness estimation in healthy subjects: a validation of oscillometric (Arteriograph) and tonometric (SphygmoCor) techniques2014 · 87 citations
  4. 4The prognostic value of arterial stiffness in systolic heart failure2013 · 29 citations
  5. 5A new oscillometric method for assessment of arterial stiffness: comparison with tonometric and piezo-electronic methods2008 · 320 citations