September 1, 1990European Journal of BiochemistryOpen Access

Heat capacity and entropy changes of troponin C from bullfrog skeletal muscle induced by calcium binding

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Population

Bullfrog skeletal muscle troponin C (TnC)

Comparison

Calcium binding in the absence and presence of… vs Absence vs presence of 5 mM Mg2+

Design

Preclinical

Authors

MIMasamoto ImaizumiCenter for Science in the Public Interest (United States)MTMasaru TanokuraTokyo University of Pharmacy and Life Sciences

Discussion

Member takes

Implication

Hypothesis-generating for TnC site 3 as regulatory in skeletal muscle; leaves open translation to mammalian cardiac contraction.

Structured PICO

Population

Bullfrog skeletal muscle troponin C (TnC)

Intervention

Calcium (Ca2+) binding in the absence and presence of Mg2+ at pH 7.0, and at 5, 15, and 25 degrees C

Comparator

Absence vs presence of 5 mM Mg2+

Outcome

Heat capacity and entropy changes (conformational changes)surrogate

Ca2+ binding to site 3 of bullfrog skeletal muscle troponin C exposes hydrophobic groups and increases molecular mobility, suggesting it acts as the regulatory site in muscle contraction.

Cite This Study

Imaizumi et al. (1990) studied this question.

synapsesocial.com/papers/6a982fc8c5cc395bb1e17d39 https://doi.org/10.1111/j.1432-1033.1990.tb19224.x

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Heat capacity and entropy changes of troponin C from bullfrog skeletal muscle induced by calcium binding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Heat capacity and entropy changes of troponin C from bullfrog skeletal muscle induced by calcium binding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider