Identification of Novel Import and Export Signals of Human TAP, the Protein That Binds to the Constitutive Transport Element of the Type D Retrovirus mRNAs

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Structured PICO

Population

Human TAP (hTAP) protein and its interaction with the constitutive transport RNA element (CTE) of type D retrovirus mRNAs

Intervention

Identification and characterization of nuclear import (NLS) and export (NES) signals

Outcome

Characterization of hTAP protein structure, subcellular localization, and bidirectional trafficking signals

The study characterizes the human TAP protein as a dynamic bidirectional transporter across the nuclear envelope, supporting its role in mRNA export.

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Defines hTAP bidirectional trafficking in models; leaves open human mRNA export validation and therapeutic targeting.

Bear et al. (1999) studied this question.

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