NH4Cl rapidly and reversibly inhibits cell fusion induced by HSV-1 syn mutants without affecting viral replication, suggesting direct interference with the fusion mechanism.
Hypothesis-generating for NH4Cl as HSV fusion inhibitor; leaves open in vivo relevance or therapeutic potential.
Cell fusion induced by syn mutants of herpes simplex virus type 1 is inhibited by NH4Cl. The inhibition of fusion is both rapid and rapidly reversible and apprears to be due to the NH4+ ion. Virus production was not significantly altered by NH4Cl, although cell growth was greatly diminished.
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Holland et al. (1977) studied this question.
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