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Lipid biosynthesis from glucose was increased in severe acne both in dermis and in epidermis which included the top portions of the pilosebaceous follicles. Both tissues retained their characteristic lipid labelling pattern. The magnitude of the increase in dermis and epidermis was similar, suggesting that epidermis may be subject to the same sebotrophic-lipogenic stimulus which affects sebaceous glands.
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Shuster et al. (1980) studied this question.
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