Key result
Hemodialysis significantly reduced both augmentation index (19%; p=0.003) and ADMA levels (17%; p<0.001), with the magnitudes of these changes being correlated (r=0.44; p=0.045).
Why the study?
Does a hemodialysis session improve central arterial pressure waveform and reduce ADMA levels in chronic hemodialysis patients?
Observational (n=32)
Does a hemodialysis session improve central arterial pressure waveform and reduce ADMA levels in chronic hemodialysis patients?
p-value: p=0.003 for AIx; <0.001 for ADMA
Hemodialysis acutely reduces ADMA levels and improves central arterial pressure waveforms, suggesting a role for nitric oxide in regulating arterial stiffness in hemodialysis patients.
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Hypothesis-generating for nitric oxide modulation of arterial stiffness; prospective trials needed before clinical adoption.
Soveri et al. (2007) conducted an observational in Chronic hemodialysis (n=32). Hemodialysis vs. Before hemodialysis (baseline) was evaluated on Changes in ADMA levels and central arterial pressure waveform (Augmentation index) (p=0.003 for AIx; <0.001 for ADMA). Hemodialysis significantly reduced both augmentation index (19%; p=0.003) and ADMA levels (17%; p<0.001), with the magnitudes of these changes being correlated (r=0.44; p=0.045).
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