Why the study?
Does the type of dialyzer affect plasma dimethylarginine and L-arginine levels in chronic hemodialysis patients?
Does the type of dialyzer affect plasma dimethylarginine and L-arginine levels in chronic hemodialysis patients?
The type of dialyzer does not significantly impact long-term plasma dimethylarginine levels in chronic hemodialysis patients, as variability is primarily driven by patient factors.
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Membrane choice does not alter long-term dimethylarginine levels in HD; confirms patient factors dominate variability over dialyzer type.
BACKGROUND: Asymmetric dimethylarginine (ADMA) levels are increased in hemodialysis (HD) patients. Reports on the effect of various dialysis strategies on ADMA, symmetric dimethylarginine (SDMA) and L-arginine levels are inconclusive. PATIENTS/METHODS: In this randomized crossover study, 15 patients were dialyzed for 4 weeks with 4 dialyzers, differing in biocompatibility and flux. Dimethylarginine and L-arginine levels were assessed at baseline, and after 4 weeks both before and after HD. RESULTS: During HD, ADMA and SDMA levels decreased significantly with all dialyzers. Dimethylarginine and L-arginine levels remained stable after 4 weeks of HD with each membrane. After pooling all data, values were mainly explained by variation between time points and patients, not by the type of dialyzer. CONCLUSION: Despite an intradialytic decrease in dimethylarginines, no changes occurred after 4 weeks of HD with either membrane. Furthermore, the variability of AMDA, SDMA and L-arginine levels was far more dependent on patient-related factors than on the type of dialyzer applied.
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Grooteman et al. (2007) studied this question.
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