January 4, 2017European Journal of Cardio-Thoracic Surgery
Can Perceval sutureless valve reduce the rate of patient-prosthesis mismatch?†
Key result
Aortic valve replacement with the Perceval sutureless bioprosthesis resulted in a 0% incidence of patient-prosthesis mismatch compared to 61.3% with conventional sutured valves (P<0.001).
Why the study?
Does sutureless aortic valve replacement with the Perceval bioprosthesis reduce the incidence of patient-prosthesis mismatch compared to conventional sutured bioprosthesis in patients with severe symptomatic aortic stenosis?
Population
124 matched patients with severe symptomatic aortic stenosis undergoing aortic valve replacement. Matched…
Comparison
Sutureless aortic valve replacement with the… vs Conventional sutured bioprosthesis
Design
Cohort
Authors
Discussion
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Member takes
Implication
May reduce PPM after aortic valve replacement; hypothesis-generating and requires randomized confirmation before practice change.
Study Design
Type
Cohort (n=242)
Multicenter
Yes
Structured PICO
Does sutureless aortic valve replacement with the Perceval bioprosthesis reduce the incidence of patient-prosthesis mismatch compared to conventional sutured bioprosthesis in patients with severe symptomatic aortic stenosis?
P
Population
242 patients with severe symptomatic aortic stenosis undergoing aortic valve replacement, analyzed as 62 exactly matched pairs based on sex and body surface area.
E
Exposure
Sutureless aortic valve replacement with the Perceval bioprosthesis
C
Comparator
Conventional sutured bioprosthesis
O
Outcome
Incidence of patient-prosthesis mismatch (PPM) and indexed effective orifice areasurrogate
Main Result
Absolute Event Rate: 0% vs 61.3%
p-value: p=<0.001
Sutureless aortic valve replacement with the Perceval bioprosthesis significantly increases the indexed effective orifice area and eliminates patient-prosthesis mismatch compared to conventional sutured valves in matched patients with severe aortic stenosis.
Cite This Study
Belluschi et al. (2017) conducted a cohort in severe symptomatic aortic stenosis (n=242). Perceval sutureless bioprosthesis vs. Conventional sutured bioprosthesis was evaluated on Patient-prosthesis mismatch (PPM) (p=<0.001). Aortic valve replacement with the Perceval sutureless bioprosthesis resulted in a 0% incidence of patient-prosthesis mismatch compared to 61.3% with conventional sutured valves (P<0.001).