Key result
Each copy of the common three-locus IL1-CCC haplotype was associated with a 21% increased risk of coronary artery disease (OR 1.21), with a stronger effect observed in early-onset cases.
Why the study?
Do inflammatory gene polymorphisms increase the risk of premature coronary artery disease in discordant sibships?
Population
2,699 individuals in 891 families from the UK. Premature CAD defined as validated MI, PTCA, CABG or angina…
Comparison
Presence of 48 coding and 3 non-coding single… vs Unaffected siblings (median age 57 years)
Design
Case-control
Authors
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Should not yet inform CAD risk stratification; hypothesis-generating for IL-1 variants in premature disease.
Observational (n=2,699)
Yes
Do inflammatory gene polymorphisms increase the risk of premature coronary artery disease in discordant sibships?
Odds Ratio: 1.21 (95% CI 1.04–1.4)
p-value: p=0.01
A common three-locus haplotype in the interleukin-1 gene cluster is associated with an increased risk of premature coronary artery disease, particularly in younger individuals, though this effect may be related to hypercholesterolemia.
Brown et al. (2010) conducted an observational in Premature coronary artery disease (n=2,699). IL1-CCC haplotype vs. Fewer or no copies of the IL1-CCC haplotype was evaluated on Development of coronary artery disease (CAD) (OR 1.21, 95% CI 1.04-1.40, p=0.01). Each copy of the common three-locus IL1-CCC haplotype was associated with a 21% increased risk of coronary artery disease (OR 1.21), with a stronger effect observed in early-onset cases.
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