Key result
Low dose of argatroban saline flushes reduced clot formation and improved dialysis efficiency compared to heparin-free anticoagulation across 80 hemodialysis sessions.
Why the study?
Does low dose of argatroban saline flushes reduce clot formation and improve dialysis efficiency compared to heparin-free anticoagulation in hemodialysis patients with high risk of bleeding?
Observational (n=80)
Does low dose of argatroban saline flushes reduce clot formation and improve dialysis efficiency compared to heparin-free anticoagulation in hemodialysis patients with high risk of bleeding?
Low dose argatroban saline flushes provide a feasible and safe anticoagulation alternative that reduces clot formation and improves dialysis efficiency in hemodialysis patients at high risk of bleeding.
Answers are grounded in this paper and cite their sources.
May support argatroban flushes in high-bleeding-risk hemodialysis; leaves open randomized confirmation.
BACKGROUND: Anticoagulation in hemodialysis (HD) patients with high risk of bleeding is still an intractable problem. METHOD: A total of 80 HD sessions with high risk of bleeding were completed with either heparin-free (HF) or low dose of argatroban saline flushes (LASF) anticoagulation. Clinical clot formation in the pipeline and dialyzer was inspected to evaluate the local anticoagulation efficiency; prothrombin time (PT), activated partial thromboplastin time (aPTT), and D-dimer were tested to investigate the influence on the whole body coagulation system; urea reduction ratio (URR) and Kt/V were used to evaluate the efficiency of dialysis. RESULTS: Comparing with HF, LASF showed a satisfactory efficiency in reducing the clot formation and the URR and Kt/V of it were also higher. CONCLUSIONS: Low dose of argatroban saline flushes is a feasible and safe alternative anticoagulation protocol in HD patients with high risk of bleeding.
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Li et al. (2009) conducted an observational in Hemodialysis with high risk of bleeding (n=80). Low dose of argatroban saline flushes vs. Heparin-free anticoagulation was evaluated on Clinical clot formation in the pipeline and dialyzer, urea reduction ratio (URR), and Kt/V. Low dose of argatroban saline flushes reduced clot formation and improved dialysis efficiency compared to heparin-free anticoagulation across 80 hemodialysis sessions.
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