What question did this study set out to answer?

Determine how physiologic pH changes and carbon dioxide diffusion influence epinephrine- and ADP-induced human platelet aggregation.

April 1, 1972Experimental Biology and Medicine

The Effect of pH on Human Platelet Aggregation Induced by Epinephrine and ADP

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Authors

ARA. B. RogersCancer Research UK

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Implication

In vitro experiment demonstrates pH-dependent modulation of platelet aggregation in human plasma, suggesting acid-base shifts alter clotting responses.

Key Points

Determine how physiologic pH changes and carbon dioxide diffusion influence epinephrine- and ADP-induced human platelet aggregation.
Layered carbon dioxide-enriched air over platelet-rich plasma samples to prevent alkaline pH drift caused by carbon dioxide loss.
Measured in vitro human platelet aggregation and disaggregation responses to epinephrine and ADP across varying physiologic pH levels.
Acidosis inhibited epinephrine-induced platelet aggregation, whereas alkalosis enhanced aggregation within the physiologic range.
ADP-induced platelet aggregation demonstrated lower overall pH dependency, but acidic pH markedly increased the rate and extent of disaggregation.

Cite This Study

A. B. Rogers (1972) studied this question.

synapsesocial.com/papers/6a984522161d47660415ff8e https://doi.org/10.3181/00379727-139-36307

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Implication

In vitro experiment demonstrates pH-dependent modulation of platelet aggregation in human plasma, suggesting acid-base shifts alter clotting responses.

The Effect of pH on Human Platelet Aggregation Induced by Epinephrine and ADP

Discussion

Member takes

Implication

Key Points

Cite This Study

The Effect of pH on Human Platelet Aggregation Induced by Epinephrine and ADP

Discussion

Member takes

Implication

Key Points

Cite This Study

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