Key result
Circulating levels of miR-122, miR-130a, and miR-486 are significantly influenced by aortic valve morphology, while miR-718 expression is inversely correlated with aortic diameter (R = -0.63, p = 3.1 x 10^-5) and serves as an independent predictor of aortic dilation.
Cross-Sectional (n=67)
No
Effect estimate: R = -0.63
p-value: p=3.1 x 10^-5
Circulating miR-122, miR-130a, miR-486, and miR-718 serve as potential biomarkers for bicuspid aortic valve and aortic dilation, with miR-718 independently predicting aortic dilation.
No takes yet. Share an insight, caveat, or question.
miR-718 should not yet guide aortic surveillance; hypothesis-generating for these miRNAs as biomarkers in bicuspid valve disease.
Martínez-Micaelo et al. (2017) conducted a cross-sectional in Bicuspid aortic valve disease and aortic dilation (n=67). Bicuspid aortic valve and aortic dilation vs. Healthy tricuspid aortic valve individuals was evaluated on Correlation between circulating miR-718 expression and ascending aortic diameter (R = -0.63, p=3.1 x 10^-5). Circulating levels of miR-122, miR-130a, and miR-486 are significantly influenced by aortic valve morphology, while miR-718 expression is inversely correlated with aortic diameter (R = -0.63, p = 3.1 x 10^-5) and serves as an independent predictor of aortic dilation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: