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March 12, 2015PLoS ONEOpen Access

Neonatal Infection with Species C Adenoviruses Confirmed in Viable Cord Blood Lymphocytes

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Population

517 umbilical vein cord blood samples from infants born at Grady Memorial Hospital in Atlanta, Georgia…

Design

Cross-sectional

Key result

Species C adenoviral DNA was identified in 3.7% of viable cord blood lymphocyte samples from 517 neonates, providing definitive evidence for the occurrence of prenatal adenovirus infection.

Authors

DODavid A. OrnellesLGL R GoodingCGCharlie Garnett‐Benson

Discussion

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Overview

May implicate prenatal adenovirus in childhood ALL risk; leaves open causal confirmation in prospective cohorts.

Study Design

Type

Cross-Sectional (n=517)

Multicenter

No

Structured PICO

P
Population
517 neonates born at a single hospital in Atlanta, Georgia, whose umbilical cord blood lymphocytes were screened for adenoviral DNA and the ETV6-RUNX1 translocation.
O
Outcome
Presence of species C adenoviral DNA in viable cord blood lymphocytessurrogate

This study provides definitive evidence of prenatal infection with species C adenoviruses in a significant fraction of neonates, which may be relevant to the genesis of childhood acute lymphoblastic leukemia.

Limitations

  • Limited number of samples analyzed for the ETV6-RUNX1 translocation, lacking sufficient statistical power to establish an association with adenoviral DNA.
  • Non-random selection of samples tested for the ETV6-RUNX1 translocation may skew the estimated fraction of cord blood with the fusion transcript.
  • Limited number of samples analyzed for the ETV6-RUNX1 translocation, reducing statistical power to establish an association
  • Non-random selection of samples tested for the ETV6-RUNX1 translocation

Cite This Study

Ornelles et al. (2015) conducted a cross-sectional in Prenatal Adenovirus Infection (n=517). Species C adenovirus infection vs. Unexposed (adenovirus-negative) was evaluated on Detection of species C adenoviral DNA in viable cord blood lymphocytes (95% CI 2.4-5.7). Species C adenoviral DNA was identified in 3.7% of viable cord blood lymphocyte samples from 517 neonates, providing definitive evidence for the occurrence of prenatal adenovirus infection.

synapsesocial.com/papers/6a9846d31a776067eb23c774https://doi.org/10.1371/journal.pone.0119256
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