Key result
Chronic infection of lymphoid cells by adenovirus types 5 and 6 is maintained by cell-to-cell spread in the absence of antibody and intracellular persistence in the presence of antibody.
Population
Primary mononuclear leukocytes from human umbilical cord blood and Epstein-Barr virus-transformed B…
Design
Preclinical
Follow-up
two to three months
Authors
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Chronic adenovirus infection persists in leukocytes and B cells without cytopathic effects; leaves open the clinical relevance of lymphoid latency.
Adenovirus can establish chronic infection in lymphoid cells via cell-to-cell spread and intracellular persistence.
Andiman et al. (1982) studied Adenovirus infection. Adenovirus types 5 and 6 was evaluated on Recovery of adenovirus from cultures. Chronic infection of lymphoid cells by adenovirus types 5 and 6 is maintained by cell-to-cell spread in the absence of antibody and intracellular persistence in the presence of antibody.
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