What question did this study set out to answer?

To determine how the LIM homeodomain transcription factor Apterous mediates cell-specific expression of the Drosophila FMRFa neuropeptide gene.

December 1, 1998Development

Cell type-specific regulation of the Drosophila FMRF-NH 2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor

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To determine how the LIM homeodomain transcription factor Apterous mediates cell-specific expression of the Drosophila FMRFa neuropeptide gene.
Mapped expression patterns of Apterous and the dFMRFa gene across Drosophila central nervous system subsets, focusing on Tv neuroendocrine cells and SP2 interneurons.
Evaluated the impact of Apterous loss-of-function and ectopic expression on dFMRFa initiation, postembryonic maintenance, and Tv cell differentiation.
Apterous directly initiated and contributed to the postembryonic maintenance of dFMRFa expression specifically in Tv neuroendocrine cells.
Tv neuron survival and morphological differentiation remained unaffected in the absence of Apterous.
Ectopic Apterous expression failed to trigger dFMRFa in non-expressing lineages, indicating that Apterous requires cell-specific co-factors to activate expression.

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Implication

Genetic analysis reveals cell-specific regulation of the FMRFa neuropeptide gene by Apterous in Drosophila Tv neurons, indicating modular control of neurotransmitter expression.

Cite This Study

Benveniste et al. (1998) studied this question.

synapsesocial.com/papers/6a9848e8ce42e14121e1968c https://doi.org/10.1242/dev.125.23.4757

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Implication

Genetic analysis reveals cell-specific regulation of the FMRFa neuropeptide gene by Apterous in Drosophila Tv neurons, indicating modular control of neurotransmitter expression.

Cell type-specific regulation of the Drosophila FMRF-NH 2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor

Key Points

Discussion

Implication

Cite This Study

Cell type-specific regulation of the Drosophila FMRF-NH 2 neuropeptide gene by Apterous, a LIM homeodomain transcription factor

Key Points

Discussion

Implication

Cite This Study

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