What question did this study set out to answer?

Investigate how the selector gene Apterous is temporally regulated by its target dLMO during Drosophila wing dorsoventral axis formation.

July 15, 2000Development

Temporal regulation of Apterous activity during development of the Drosophila wing

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Authors

MMMarco MilánInstitució Catalana de Recerca i Estudis Avançats SCStephen M. CohenUniversity of North Carolina at Chapel Hill

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Implication

Experimental genetic study reveals that dLMO negatively regulates Apterous during Drosophila wing development, indicating that timing limits Notch organizer induction.

Key Points

Investigate how the selector gene Apterous is temporally regulated by its target dLMO during Drosophila wing dorsoventral axis formation.
Assessed spatial and temporal expression profiles of Apterous, dLMO, Serrate, fringe, and delta in the developing Drosophila wing primordium.
Examined cellular differentiation, cell survival, and Notch pathway activation under conditions of Apterous overactivation in the absence of dLMO.
Apterous induces expression of its negative regulator dLMO, which subsequently downregulates Serrate and fringe while permitting delta expression in dorsal cells.
Feedback inhibition by dLMO establishes a restricted temporal window for localized Notch activation and organizer induction along the dorsoventral compartment boundary.
Loss of dLMO-mediated Apterous downregulation causes Serrate overexpression, delta repression, and significant differentiation and cell survival defects in the wing primordium.

Cite This Study

Milán et al. (2000) studied this question.

synapsesocial.com/papers/6a98ce56d71845e702aa86d2 https://doi.org/10.1242/dev.127.14.3069

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Implication

Experimental genetic study reveals that dLMO negatively regulates Apterous during Drosophila wing development, indicating that timing limits Notch organizer induction.

Temporal regulation of Apterous activity during development of the Drosophila wing

Discussion

Member takes

Implication

Key Points

Cite This Study

Temporal regulation of Apterous activity during development of the Drosophila wing

Discussion

Member takes

Implication

Key Points

Cite This Study

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