What question did this study set out to answer?

To evaluate the prognostic significance of human papillomavirus status and p16 immunohistochemical expression in clinical outcomes for penile squamous cell carcinoma.

July 21, 2023CancersOpen Access

The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review

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Authors

KPKevin ParzaJacksonville University AMArfa MustasamMoffitt Cancer Center FIFilip IonescuMoffitt Cancer Center

Discussion

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Implication

Systematic review reveals improved survival outcomes for HPV- and p16-positive penile squamous cell carcinoma, highlighting the need for standardized testing in routine diagnosis.

Key Points

To evaluate the prognostic significance of human papillomavirus status and p16 immunohistochemical expression in clinical outcomes for penile squamous cell carcinoma.
Conducted a systematic review adhering to PRISMA guidelines across PubMed, Embase, and Cochrane databases.
Identified and reviewed 34 eligible studies, comprising 33 retrospective cohort studies and one cross-sectional study.
Nine studies reported that HPV-positive and p16-positive penile squamous cell carcinomas were associated with improved overall survival and disease-free survival.
Evidence remains derived primarily from retrospective observational cohorts, demonstrating the need for future meta-analyses to confirm the value of routine HPV and p16 staging.

Cite This Study

Parza et al. (2023) studied this question.

synapsesocial.com/papers/6a984e9c3de45e4adad7e954 https://doi.org/10.3390/cancers15143713

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Implication

Systematic review reveals improved survival outcomes for HPV- and p16-positive penile squamous cell carcinoma, highlighting the need for standardized testing in routine diagnosis.

The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

The Prognostic Role of Human Papillomavirus and p16 Status in Penile Squamous Cell Carcinoma—A Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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