Key result
A history of atrial fibrillation was associated with an approximately 10% higher prevalence of microalbuminuria in hypertensive patients.
Why the study?
Does a history of atrial fibrillation correlate with increased prevalence of microalbuminuria in hypertensive patients?
Cross-Sectional (n=20,605)
Yes
Does a history of atrial fibrillation correlate with increased prevalence of microalbuminuria in hypertensive patients?
In hypertensive patients, a history of atrial fibrillation and higher heart rate are independently associated with an increased prevalence of microalbuminuria.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for microalbuminuria screening in hypertensive AF patients; prospective studies needed to assess causality and impact.
AIMS: To investigate the relationship between microalbuminuria (MAU) and atrial fibrillation (AF) and to further evaluate whether the heart rate dependency of MAU in patients without AF is maintained in patients with a history of AF. METHODS AND RESULTS: The International Survey Evaluating Microalbuminuria Routinely by Cardiologists in patients with Hypertension (I-SEARCH) included 18,900 patients without and 1705 patients with a history of AF suffering from hypertension and other risk factors for cardiovascular disease in 26 countries worldwide from September 2005 to March 2006. Heart rate, blood pressure, urinary albumin excretion, and an estimated glomerular filtration rate were determined among other parameters. The prevalence of MAU was higher at higher heart rate in both patients with and without a history of AF. Prevalence of MAU was about 10% higher in patients with a history of AF (P < 0.001). Male gender, the presence of diabetes mellitus, a higher heart rate, and a higher diastolic blood pressure were independently associated with increased odds for MAU in patients without and with a history of AF. CONCLUSION: The prevalence of MAU in hypertensive patients with cardiovascular risk factors is related to heart rate and significantly higher in patients with a history of AF.
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Böhm et al. (2009) conducted a cross-sectional in Hypertension (n=20,605). History of atrial fibrillation vs. No history of atrial fibrillation was evaluated on Prevalence of microalbuminuria (MAU) (p=<0.001). A history of atrial fibrillation was associated with an approximately 10% higher prevalence of microalbuminuria in hypertensive patients.
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