Key result
High-sensitivity cardiac troponin T was independently associated with higher SYNTAX score and diabetes in patients with stable coronary artery disease.
Why the study?
Is high-sensitivity cardiac troponin T associated with the extent and complexity of CAD (SYNTAX score) in patients with stable CAD?
Observational (n=411)
Is high-sensitivity cardiac troponin T associated with the extent and complexity of CAD (SYNTAX score) in patients with stable CAD?
In patients with stable CAD, higher hs-cTnT concentrations are independently associated with greater extent and complexity of CAD as measured by the SYNTAX score.
Answers are grounded in this paper and cite their sources.
hs-cTnT may signal greater CAD complexity in stable disease; leaves open its incremental value for risk stratification beyond SYNTAX.
High-sensitivity cardiac troponin T (hs-cTnT) and the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score are emerging as important prognostic markers in stable coronary artery disease (CAD). We aimed to investigate the relationship between hs-cTnT and extent and complexity of CAD assessed with STNTAX score. Measurements were obtained from 411 patients with stable CAD (Mean age=61.7 ± 9.9 years, male/female=247/164). The patients were divided into two groups according to the median hs-TnT value (hs-cTnTlow group<9.65 pg/ml and hs-cTnThigh group ≥ 9.65 pg/ml). SYNTAX score values were higher in hs-cTnThigh group compared with hs-cTnTlow group (p<0.05). Hs-cTnT was independently associated with SYNTAX score (β=0.661, p<0.001) and diabetes (β=0.107, p=0.031) in multiple linear regression analysis. The cutoff value of hscTnT obtained by the ROC curve analysis was 9.62 ng/L for the prediction of higher SYNTAX score. In multivariate logistic regression analysis, hs-cTnT, age, diabetes, creatinine and hs-CRP were an independent predictor for higher SYNTAX score. Despite very low circulating concentrations, changes in hs-cTnT concentrations are associated with extent and complexity of CAD and presence of diabetes in patients with stable CAD.
No takes yet. Share an insight, caveat, or question.
Onur Kaypakl Nermin Yıldız Koyunsever (2013) conducted an observational in Stable coronary artery disease (n=411). High-sensitivity cardiac troponin T (hs-cTnT) vs. Low hs-cTnT (<9.65 pg/ml) was evaluated on SYNTAX score (β=0.661, p=<0.001). High-sensitivity cardiac troponin T was independently associated with higher SYNTAX score and diabetes in patients with stable coronary artery disease.
Synapse has enriched 10 related papers. Consider them for comparative context: