Synthetic study demonstrates direct C3-H trifluoromethylthiolation of quinoxalin-2(1H)-ones, highlighting an efficient radical pathway using earth-abundant iron.
An iron‐catalyzed direct C3−H radical trifluoromethylthiolation of quinoxalin‐2(1H)‐ones has been developed. This protocol uses earth‐abundant FeSO4 ⋅ 7H2O as the catalyst, and AgSCF3 as the trifluoromethylthiolating reagent to provide various SCF3‐containing quinoxalin‐2(1H)‐one derivatives in 26–88% yields. Preliminary mechanistic investigations indicate that the reaction proceeds through a radical pathway.
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Chen et al. (2023) studied this question.
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