Key result
Oxymatrine attenuated doxorubicin-induced oxidative stress, pathological damage, and apoptosis in rat hearts and H9c2 cells.
Why the study?
Does oxymatrine prevent doxorubicin-induced cardiotoxicity in rat hearts and H9c2 cells?
Population
Rat hearts and H9c2 cells with doxorubicin-induced cardiotoxicity
Comparison
Oxymatrine vs Doxorubicin alone
Design
Preclinical
Authors
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Supports oxymatrine cardioprotection in rat doxorubicin models; leaves open translation to clinical use.
Does oxymatrine prevent doxorubicin-induced cardiotoxicity in rat hearts and H9c2 cells?
Oxymatrine shows potential as a cardioprotective agent against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and apoptosis in preclinical models.
Zhang et al. (2017) studied Doxorubicin-induced cardiotoxicity. Oxymatrine was evaluated on Oxidative stress, pathological damage, and apoptosis. Oxymatrine attenuated doxorubicin-induced oxidative stress, pathological damage, and apoptosis in rat hearts and H9c2 cells.
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