Mechanism of Ventricular Defibrillation for Near-Defibrillation Threshold Shocks
Why the study?
Does the electrical state of the heart at the time of shock and repolarization time determine defibrillation outcome in isolated pig hearts?
Population
6 isolated pig hearts
Comparison
10 DFT(50) biphasic shocks vs Successful defibrillation versus failed…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Near-threshold defibrillation success correlates with shock timing and repolarization in isolated hearts; leaves open whether these parameters inform clinical strategies.
Structured PICO
Does the electrical state of the heart at the time of shock and repolarization time determine defibrillation outcome in isolated pig hearts?
P
Population
6 isolated pig hearts
I
Intervention
10 DFT(50) biphasic shocks
C
Comparator
Successful defibrillation (SDF) versus failed defibrillation (FDF) episodes
O
Outcome
Global cardiac activation and recovery (coupling interval [CI] and time to 90% repolarization [RT90])surrogate
For near-threshold shocks, defibrillation outcome correlates with the electrical state of the heart at the time of the shock and repolarization time, rather than global dispersion of repolarization.
Cite This Study
Chattipakorn et al. (2001) studied this question.