Prognostic Implication of Platelet Reactivity According to Procedural Complexity After PCI

Figures

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  Figure 1. Study Flow Diagram A total of 13,160 participants from the PTRG-DES (Platelet Function and Genotype-Related Long-Term Prognosis in DES-Treated Patients) consortium treated with drug-eluting stents were enrolled between July 2003 and August 2018. Patients in the platelet function test cohort (PFT) (n = 11,714) were classified according to procedural complexity and platelet reactivity. High platelet reactivity (HPR) criteria were determined using VerifyNow (≥252 P2Y12 reaction units). The primary endpoint was the occurrence of major adverse cardiac and cerebrovascular events (MACCE) including all-cause death, nonfatal myocardial infarction (MI), definite stent thrombosis (ST), or nonfatal stroke during the 3-year follow-up period. PCI = percutaneous coronary intervention.

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  Central Illustration. Clinical Outcomes of Procedural Complexity in Patients Undergoing Percutaneous Coronary Intervention (A) Proportion of complex percutaneous coronary intervention (PCI), high platelet reactivity (HPR), and subtype of complex PCI. (B) The cumulative incidence of major adverse cardiac and cerebrovascular events (MACCE) according to complex PCI. (C) Prognostic implication of HPR according to presence of complex PCI.

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  Figure 2. Kaplan-Meier Curves for MACCE and Death According to Complex PCI Kaplan-Meier estimates were conducted between the 2 groups for (A) MACCE and (B) death according to the complexity of PCI. Bonferroni’s correction was applied for multiple comparisons between the 2 groups. Abbreviations as in Figure 1.

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  Figure 3. Incidence Rate of MACCE According to Quartile Distribution of PRU Incidence rate of MACCE between complex PCI (A) and noncomplex PCI (B) according to quartile distribution of P2Y12 reaction unit (PRU). Bonferroni’s correction was applied for multiple comparisons between the 2 groups. Abbreviations as in Figure 1.

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  Figure 4. Kaplan-Meier Curves for MACCE and Death by PCI and HPR Kaplan-Meier estimates were conducted among the 4 groups for (A) MACCE and (B) death according to complex PCI and HPR. Bonferroni’s correction was applied for multiple comparisons among the 4 groups. Abbreviations as in Figure 1.

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  Figure 5. Impacts of HPR on MACCE and Major Bleeding (A and C) subtype of complex PCI and (B and D) the extent of procedural complexity. Abbreviations as in Figures 1 and 2.