Why the study?
Does the infusion of epinephrine and norepinephrine alter the arterial pulse wave in normotensive subjects?
Does the infusion of epinephrine and norepinephrine alter the arterial pulse wave in normotensive subjects?
This study investigates the physiological mechanisms of arterial pulse wave changes during transient hypertension induced by catecholamines.
Does not change clinical practice; extends mechanistic understanding of catecholamine effects on pulse waves for future research.
Previous studies have shown abnormalities of the arterial pulse wave in hypertensive subjects of all age groups. The major change has been diminution to disappearance of the dicrotic wave. The pharmacologic differences between epinephrine and norepinephrine offer a means of studying the mechanism of this change in the dicrotic wave. In the present study, normotensive subjects have had transient hypertension induced by the infusion of epinephrine and norepinephrine. The different effects of these drugs on their arterial pulse waves have been recorded.
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Feinberg et al. (1958) studied this question.
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