Key result
Free polyunsaturated fatty acids modulate the final voltage sensor movement of the voltage-gated Shaker K channel, an effect dependent on specific charges at the extracellular end of the sensor.
Population
Voltage-gated Shaker K channel model
Design
Preclinical
Authors
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May guide future antiarrhythmic drug design; leaves open translation from this animal model to patients.
Identifying the specific binding site and mechanism of PUFAs on voltage-gated K channels provides a potential target for designing small-molecule drugs to treat cardiac arrhythmias and epileptic seizures.
Börjesson et al. (2011) studied this question. Free polyunsaturated fatty acids (PUFAs) was evaluated on Site of action and mechanism of PUFAs on the voltage-gated Shaker K channel. Free polyunsaturated fatty acids modulate the final voltage sensor movement of the voltage-gated Shaker K channel, an effect dependent on specific charges at the extracellular end of the sensor.
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