Key result
Polyunsaturated fatty acids modify the gating of Kv1.5 and Kv11.1 channels by acting as open-channel blockers and shifting activation voltages, indicating that Kv channel gating is lipid-dependent.
Population
Voltage-gated potassium channels (Kv1.5 and Kv11.1)
Design
Review
Authors
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May link PUFAs to antiarrhythmic Kv modulation; leaves open clinical translation and requires prospective human studies.
Polyunsaturated fatty acids exert antiarrhythmic effects by directly modulating the gating properties of cardiac voltage-gated potassium channels.
Moreno et al. (2012) conducted a review in Kv channel gating modulation. Polyunsaturated fatty acids (PUFAs) was evaluated. Polyunsaturated fatty acids modify the gating of Kv1.5 and Kv11.1 channels by acting as open-channel blockers and shifting activation voltages, indicating that Kv channel gating is lipid-dependent.
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