Key result
The presence of any two out of three characteristic pleuroscopic features (sago-like nodules/micronodules, adhesion, and discrete distribution) yielded a positive predictive value of 100.0% and a negative predictive value of 93.7% for diagnosing tuberculosis pleurisy.
Why the study?
Diagnosis of tuberculosis pleurisy remains challenging in pleural effusion of unknown origin after aspiration analysis, prompting evaluation of a simple pleuroscopic image interpretation technique.
Does the presence of specific pleuroscopic features (sago-like nodules, adhesion, discrete distribution) accurately diagnose TB pleurisy in patients with undiagnosed pleural effusion?
Population
117 patients undergoing semi-rigid pleuroscopy in a tertiary hospital
Comparison
TB pleurisy vs non-TB pleurisy evaluation via three pleuroscopic image features
Design
Retrospective observational study
Authors
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The presence of any two out of three specific pleuroscopic features (sago-like nodules, adhesion, discrete distribution) provides a 100% positive predictive value for diagnosing TB pleurisy in patients with undiagnosed pleural effusion.
Observational (n=117)
No
Does the presence of specific pleuroscopic features (sago-like nodules, adhesion, discrete distribution) accurately diagnose TB pleurisy in patients with undiagnosed pleural effusion?
Odds Ratio: 34.6 (95% CI 10.8–110.9)
Absolute Event Rate: 71.4% vs 6.7%
p-value: p=<0.001
The presence of any two out of three specific pleuroscopic features (sago-like nodules, adhesion, discrete distribution) provides a 100% positive predictive value for diagnosing TB pleurisy in patients with undiagnosed pleural effusion.
Lee et al. (2021) conducted an observational in Undiagnosed pleural effusion (n=117). Presence of sago-like nodules or micronodules on pleuroscopy vs. Absence of sago-like nodules or micronodules was evaluated on Presence of sago-like nodules or micronodules in TB pleurisy vs non-TB pleurisy (OR 34.6, 95% CI 10.8-110.9, p=<0.001). The presence of any two out of three characteristic pleuroscopic features (sago-like nodules/micronodules, adhesion, and discrete distribution) yielded a positive predictive value of 100.0% and a negative predictive value of 93.7% for diagnosing tuberculosis pleurisy.
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