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The effect of experimental diets with calcium tofu containing casein phosphopeptides (CPP) on ovariectomy (OVX)-induced bone loss was investigated. Experimental diets containing either calcium tofu (100 mg Ca), calcium tofu containing 28 mg CPP (CPP tofu) or calcium tofu containing 28 mg dephospho CPP (dephospho CPP tofu) were freely given to sham-operated rats or OVX rats for 4 weeks. OVX caused a significant decrease in the length, dry weight and mineral density of femur. Calcium content in the femoral diaphysis and epiphysis was significantly decreased by OVX. These decreases were completely prevented by the feeding of diets with CPP tofu. Such preventive effect was not seen by the feeding of diets with dephospho CPP tofu. These results demonstrate that the diets with calcium tofu containing CPP have a preventive effect on OVX-induced bone loss due to enhancing calcium availability.
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Yamaguchi et al. (1998) studied this question.
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