Why the study?
ANGPTL4 is highly expressed in various cancers, but its regulation of energy metabolism in tumours remains to be determined.
Does ANGPTL4 regulate energy metabolism and proliferation in nonsmall cell lung cancer cells?
Population
Two NSCLC cell lines (A549 and H1299) and mice
Comparison
ANGPTL4 knockdown or overexpression vs controls
Design
Preclinical laboratory and animal study
Key result
Knockdown of ANGPTL4 inhibited energy metabolism, glutamine consumption, fatty acid oxidation, and proliferation in NSCLC cells, as well as tumor metastasis in mice.
Authors
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May identify ANGPTL4 as NSCLC metabolic target; hypothesis-generating in animal models and should not change practice.
Does ANGPTL4 regulate energy metabolism and proliferation in nonsmall cell lung cancer cells?
ANGPTL4 promotes glutamine consumption and fatty acid oxidation, driving energy metabolism and proliferation in nonsmall cell lung cancer.
Song et al. (2022) studied Non-small cell lung cancer (NSCLC). ANGPTL4 knockdown and overexpression vs. Control/normal NSCLC cells was evaluated on Energy metabolism, glutamine consumption, fatty acid oxidation, and cell proliferation. Knockdown of ANGPTL4 inhibited energy metabolism, glutamine consumption, fatty acid oxidation, and proliferation in NSCLC cells, as well as tumor metastasis in mice.